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dc.contributor.authorHussain, Samia
dc.contributor.authorSelby, Nicholas
dc.date.accessioned2020-12-08T11:37:23Z
dc.date.available2020-12-08T11:37:23Z
dc.date.issued2019-12
dc.identifier.citationKidney Int Rep. 2019 Dec 30;5(3):307-317. doi: 10.1016/j.ekir.2019.12.012.en
dc.identifier.urihttp://hdl.handle.net/20.500.12904/574
dc.description.abstractIntroduction: The underlying mechanisms of skeletal muscle wasting in hemodialysis patients are complex. We performed a systematic review to summarize evidence on whether hemodialysis has acute effects on skeletal muscle perfusion, metabolism, and function. Methods: The protocol was registered on PROSPERO (Registration number CRD42018103682). A systematic search was performed in MEDLINE, PubMed, Cochrane, Embase, Scopus, and Web of Science. Citation, reference list, and gray literature searches were also performed. Studies were selected in 2 stages: title and abstract review, then full-text review. Results: A total of 65 full-text articles were reviewed, and 14 studies were eligible for inclusion. No studies were identified that assessed muscle perfusion during dialysis. Two studies used near-infrared spectroscopy to indirectly measure skeletal muscle oxygen consumption, which increased during dialysis in 1 study but only in patients with diabetes in the second. Metabolism was examined in 9 studies. A number of acute metabolic changes were reported (e.g., caspase-3 activity, polyubiquitin, and interleukin-6 protein increased in response to hemodialysis) as was a net negative protein balance over the dialysis session. Three studies examining muscle function did not produce consistent findings. Conclusion: Gaps remain in understanding the acute effects of hemodialysis on skeletal muscle, particularly for changes in perfusion and function, although there does appear to be an acute effect on muscle metabolism.en
dc.language.isoenen
dc.subjectEnd-Stage Kidney Diseaseen
dc.subjectFunctionen
dc.subjectHemodialysisen
dc.subjectMetabolismen
dc.subjectPerfusionen
dc.subjectSkeletal Muscleen
dc.subjectSystematic Reviewen
dc.titleA Systematic Review of the Acute Effects of Hemodialysis on Skeletal Muscle Perfusion, Metabolism, and Functionen
dc.typeArticleen


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