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dc.contributor.authorShokraneh, Farhad
dc.date.accessioned2017-11-13T16:11:37Z
dc.date.available2017-11-13T16:11:37Z
dc.date.issued2017
dc.identifier.citationShahjouei, S., Sadeghi-Naini, M., Yang, Z., Kobeissy, F., Rathore, D., Shokraneh, F., Blackburn, S., Manley, G. T. & Wang, K. K. W. (2018). The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis. Brain Injury, 32(1), pp.1-17.en
dc.identifier.other10.1080/02699052.2017.1382717
dc.identifier.urihttp://hdl.handle.net/20.500.12904/6098
dc.description.abstractTraumatic brain injury (TBI) is a major health concern. The purpose of this study is to identify the diagnostic accuracy of ubiquitin C-terminal hydrolase-L1 (UCH-L1)-a protein biomarker-in comparison with CT-scan findings post-TBI. Accordingly, we conducted a systematic review of eligible studies and assessed the risk of bias according to the QUADAS-2 checklist. A total of 13 reports from 10 original studies were included. Based on our analysis, serum UCH-L1 has a high accuracy in predicting CT findings in mild to moderate TBI. Based on the QUADAS-2 checklist, this result has a high risk of bias affecting its applicability. The plasma level of UCH-L1 has moderate accuracy in predicting CT findings when assessed in all GCS levels. This result has a low risk of bias and low concerns regarding applicability. Pooled analysis suggests that the plasma/serum UCH-L1 level has high accuracy in predicting CT findings in a wide range of GCS in patients with TBI. This result has a high risk of bias and high concern about its applicability. The heterogeneity in approaching TBI biomarker interferes with drawing a definitive conclusion. Therefore, although UCH-L1 is a promising blood-based diagnostic biomarker for TBI, but due to differences in reported diagnostic accuracy, further studies are needed to recommend UCH-L1 as an alternative to CT scanning.en
dc.description.urihttp://www.tandfonline.com/doi/abs/10.1080/02699052.2017.1382717?journalCode=ibij20
dc.subjectBrain injuriesen
dc.subjectDiagnosisen
dc.titleThe diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysisen
dc.typeArticle


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