Show simple item record

dc.contributor.authordas Nair, Roshan
dc.date.accessioned2019-09-26T15:06:46Z
dc.date.available2019-09-26T15:06:46Z
dc.date.issued2019
dc.identifier.citationdas Nair, R., de Groot, V. & Freeman, J. (2019). Beyond current research practice: Methodological considerations in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?). Multiple Sclerosis Journal, 25 (10), pp.1337-1347.en
dc.identifier.other10.1177/1352458519858271
dc.identifier.urihttp://hdl.handle.net/20.500.12904/6162
dc.description.abstractRehabilitation is an essential aspect of symptomatic and supportive treatment for people with multiple sclerosis (MS). The number of randomised controlled trials (RCTs) for rehabilitation interventions in MS has increased over the last two decades. The design, conduct and reporting quality of some of these trials could be improved. There are, however, some specific challenges that researchers face in conducting RCTs of rehabilitation interventions, which are often 'complex interventions'. This paper explores some of the challenges of undertaking robust clinical trials in rehabilitation. We focus on issues related to (1) participant selection and sample size, (2) interventions - the 'dose', content, active ingredients, targeting, fidelity of delivery and treatment adherence, (3) control groups and (4) outcomes - choosing the right type, number, timing of outcomes, and the importance of defining a primary outcome and clinically important difference between groups. We believe that by following internationally accepted RCT guidelines, by developing a critical mass of MS rehabilitation 'trialists' through international collaboration and by continuing to critique, challenge, and develop RCT designs, we can exploit the potential of RCTs to answer important questions related to the effectiveness of rehabilitation interventions.en
dc.description.urihttps://journals.sagepub.com/doi/10.1177/1352458519858271en
dc.subjectRehabilitationen
dc.titleBeyond current research practice: Methodological consideration in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?)en
dc.typeArticleen


This item appears in the following Collection(s)

Show simple item record