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dc.contributor.authorPalejwala, Altaf
dc.contributor.authorMaiden, Jane
dc.contributor.authorDamant, Rose
dc.date.accessioned2017-12-29T12:02:20Z
dc.date.available2017-12-29T12:02:20Z
dc.date.issued2016-03
dc.identifier.citationHepatology. 2016 Mar;63(3):930-50. doi: 10.1002/hep.28017. Epub 2015 Oct 20.en
dc.identifier.urihttp://hdl.handle.net/20.500.12904/746
dc.description.abstractThe biochemical response to ursodeoxycholic acid (UDCA)--so-called "treatment response"--strongly predicts long-term outcome in primary biliary cholangitis (PBC). Several long-term prognostic models based solely on the treatment response have been developed that are widely used to risk stratify PBC patients and guide their management. However, they do not take other prognostic variables into account, such as the stage of the liver disease. We sought to improve existing long-term prognostic models of PBC using data from the UK-PBC Research Cohort. We performed Cox's proportional hazards regression analysis of diverse explanatory variables in a derivation cohort of 1,916 UDCA-treated participants. We used nonautomatic backward selection to derive the best-fitting Cox model, from which we derived a multivariable fractional polynomial model. We combined linear predictors and baseline survivor functions in equations to score the risk of a liver transplant or liver-related death occurring within 5, 10, or 15 years. We validated these risk scores in an independent cohort of 1,249 UDCA-treated participants. The best-fitting model consisted of the baseline albumin and platelet count, as well as the bilirubin, transaminases, and alkaline phosphatase, after 12 months of UDCA. In the validation cohort, the 5-, 10-, and 15-year risk scores were highly accurate (areas under the curve: >0.90).en
dc.language.isoenen
dc.subjectAutoimmuneen
dc.subjectCholestatic Diseaseen
dc.subjectBiliary Diseaseen
dc.titleThe UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitisen
dc.typeArticleen


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