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dc.contributor.authorHall, Charlotte L.
dc.contributor.authorBrown, Susan S.
dc.contributor.authorMartin, Jennifer L.
dc.contributor.authorBrown, Nikki
dc.contributor.authorWilliams, Laura
dc.contributor.authorSayal, Kapil
dc.contributor.authorHollis, Chris P.
dc.contributor.authorGroom, Madeleine J.
dc.date.accessioned2019-06-24T13:35:03Z
dc.date.available2019-06-24T13:35:03Z
dc.date.issued2019
dc.identifier.citationHall, C. L., Brown, S. S., James, M., Martin, J. L., Brown, N., Selby, K., Clarke, J., Williams, L., Sayal, K., Hollis, C. P., et al. (2019). Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders. BMC Medical Research Methodology, 19 (1), pp.126.en
dc.identifier.other10.1186/s12874-019-0772-2
dc.identifier.urihttp://hdl.handle.net/20.500.12904/7734
dc.description© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
dc.description.abstractBACKGROUNDThe study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their validity such as participant recruitment and retention, identifying a meaningful change, and non-adherence to the protocol. For clinical RCTs, involving patients and clinicians in protocol design provides the opportunity to develop research protocols that are meaningful to their target audience and may help overcome some of the inherent threats in conducting RCTs. However, the majority of protocols do not describe the methodology underpinning their development, limiting the amount of learned experience shared between research groups.METHODWith the purpose of reporting a collaborative approach towards developing a protocol, we present the findings from three sequential workshops that were conducted with the aim of developing a protocol to investigate the feasibility of adding a computerised test of attention, impulsivity and activity (QbTest) to medication management of children and young people with Attention deficit hyperactivity disorder (ADHD). Based on previous qualitative interviews with clinicians and families, each workshop prioritised topics for focused discussion. Information from the workshops was fed back to the participants for reflection in advance of the next workshop.RESULTSThe workshops involved 21 multi-disciplinary ADHD experts, including clinicians, patient and public involvement (PPI) members, parents of young people with ADHD and researchers. The consensus workshops addressed key research issues such as: the most relevant outcome measures/ resource drivers; methods and time points for data collection; and the clinical protocol for utilising the QbTest, including when best to use this within the medication management process. The resulting protocol details a feasibility RCT design describing these factors.CONCLUSIONProtocols which are co-developed may help overcome some of the risks associated with RCT completion (e.g. recruitment, retention, protocol adherence) and help prioritise outcomes of greater relevance to the populations under study. The methodology has potential value for researchers and organisations developing clinical guidelines, and offers insights into the valuable impact of PPI upon trial design.TRIAL REGISTRATIONClinicaltrials.gov NCT03368573, 11th December 2017 (retrospectively registered).en
dc.description.urihttps://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-019-0772-2en
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dc.subjectPatient participationen
dc.subjectAttention deficit disorder with hyperactivityen
dc.subjectComputersen
dc.titleConsensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholdersen
dc.typeArticleen
refterms.dateFOA2021-06-11T15:50:47Z


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