Show simple item record

dc.contributor.authorHorner, Daniela
dc.contributor.authorLucas, Bethany
dc.contributor.authorWhite, Kelly
dc.contributor.authorMuggleton, Andy
dc.contributor.authorSelby, Nicholas
dc.contributor.authorTaal, Maarten
dc.date.accessioned2020-12-04T10:33:09Z
dc.date.available2020-12-04T10:33:09Z
dc.date.issued2020-11
dc.identifier.citationIEEE J Transl Eng Health Med. 2020 Nov 4;9:2700209. doi: 10.1109/JTEHM.2020.3035988.en
dc.identifier.urihttp://hdl.handle.net/20.500.12904/797
dc.description.abstractObjective: Intradialytic haemodynamic instability is a significant clinical problem, leading to end-organ ischaemia and contributing to morbidity and mortality in haemodialysis patients. Non-invasive continuous blood pressure monitoring is not currently part of routine practice but may aid detection and prevention of significant falls in blood pressure during dialysis. Brachial blood pressure is currently recorded intermittently during haemodialysis via a sphygmomanometer. Current methods of continuous non-invasive blood pressure monitoring tend to restrict movement, can be sensitive to external disturbances and patient movement, and can be uncomfortable for the wearer. Additionally, poor patient blood circulation can lead to unreliable measurements. In this feasibility study we performed an initial validation of a novel method and associated technology to continuously estimate blood pressure using pressure sensors in the extra-corporeal dialysis circuit, which does not require any direct contact with the person receiving dialysis treatment. Method: The paper describes the development of the measurement system and subsequent in vivo patient feasibility study with concurrent measurement validation by Finapres Nova physiological measurement device. Real-time physiological data is collected over the entire period of (typically 4-hour) dialysis treatment. Results: We identify a quasi-linear mathematical function to describe the relationship between arterial line pressure and brachial artery BP, which is confirmed in a patient study. The results from this observational study suggest that it is feasible to derive a continuous measurement of brachial pressure from continuous measurements of arterial and venous line pressures via an empirically based and updated mathematical model. Conclusion: The methodology presented requires no interfacing to proprietary dialysis machine systems, no sensors to be attached to the patient directly, and is robust to patient movement during treatment and also to the effects of the cyclical pressure waveforms induced by the hemodialysis peristaltic blood pump. This represents a key enabling factor to the development of a practical continuous blood pressure monitoring device for dialysis patients.en
dc.language.isoenen
dc.subjectBlood Pressure Measurementen
dc.subjectContinuous Blood Pressure Measurementen
dc.subjectExtracorporeal Pressure Sensorsen
dc.subjectFistulaen
dc.subjectHemodialysisen
dc.titleA Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived From Arterial and Venous Lines During Dialysisen
dc.typeArticleen
refterms.dateFOA2021-06-03T10:09:47Z


Files in this item

Thumbnail
Name:
(732) IEEE J Transl Eng Health ...
Size:
1.112Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record