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dc.contributor.authorNixon, Neil L.
dc.date.accessioned2017-09-20T15:51:34Z
dc.date.available2017-09-20T15:51:34Z
dc.date.issued2009
dc.identifier.citationGeorgiadi, E., Liddle, P. F., Nixon, N. L. & Liotti, M. (2009). Behavioural and electrophysiological evidence for abnormal conflict monitoring in major depressive disorder. In: Krystal, J. H., (Ed.) Society of Biological Psychiatry 2009 Annual Meeting, 13-16 May 2009 Vancouver, Canada. 2009: Biological Psychiatry, p.48S-49S.
dc.identifier.other10.1016/j.biopsych.2009.03.001
dc.identifier.urihttp://hdl.handle.net/20.500.12904/8576
dc.description.abstractBackground: Previous neuroimaging studies have established the role of the Anterior Cingulate Cortex (ACC) in executive function performance, an area which has been found to be impaired in Major Depressive Disorder (MDD). However the electrophysiological indices of conflict monitoring performance have been little researched to date in both health and disease. Methods: The behavioural and electrophysiological correlates of conflict monitoring were examined in acutely depressed patients (N=15), remitted depressed patients (N=19), and their corresponding matched healthy controls. High-density ERPs (128 electrodes; Biosemi) were recorded while participants performed a Stroop colour-word interference paradigm. Results: Reaction-time results replicated the classical Stroop effect in all groups, with the acutely depressed group showing the most prolonged latencies for the incongruent than congruent trials (p=.000). In support of a previously reported early effect attributed to ACC involvement (Liotti et al., 2000), the present findings showed decreased positivity for incongruent trials versus congruent trials at 400-500ms. Although this effect was present in all groups, it was less pronounced in the acutely depressed group (p=.043). Remitted patients manifested a more similar pattern to acute patients than to controls while they also displayed a novel N450 impairment. Conclusions: These findings have helped determine the early temporal resolution of the cognitive Stroop effect in both healthy and depressed states. Consistent with cognitive impairment theories of depression, the impaired performance in the acute state reflects an executive function deficit due to illness severity while the N450 impairment in the remitted state might have implications for a trait marker in MDD.
dc.description.urihttp://www.biologicalpsychiatryjournal.com/article/S0006-3223(09)00318-7/fulltext
dc.subjectExecutive function
dc.subjectMajor depressive disorder
dc.subjectCognitive dysfunction
dc.titleBehavioural and electrophysiological evidence for abnormal conflict monitoring in major depressive disorder
dc.typeConference Proceeding


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