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dc.contributor.authorAdams, Clive E.
dc.date.accessioned2017-10-30T11:16:43Z
dc.date.available2017-10-30T11:16:43Z
dc.date.issued2010
dc.identifier.citationPope, A., Adams, C., Paton, C., Weaver, T. & Barnes, T. R. (2010). Assessment of adverse effects in clinical studies of antipsychotic medication: survey of methods used. The British Journal of Psychiatry, 197 (1), pp.67-72.en
dc.identifier.other10.1192/bjp.bp.109.070961
dc.identifier.urihttp://hdl.handle.net/20.500.12904/9769
dc.description.abstractBackground: Clinical studies of antipsychotic medication are a primary source of data on the nature of, and relative liability for, adverse effects, relevant to prescribing decisions in clinical practice. Aims: To identify how safety and tolerability data were collected and reported in recent clinical studies of antipsychotics. Method: A survey was conducted of all 167 eligible studies published between 2002 and 2007 on the Cochrane Schizophrenia Group register. Results: Extrapyramidal side-effects (EPS) and weight gain were most frequently assessed. A minority of reports addressed metabolic abnormalities, aversive subjective experiences and sexual dysfunction. Published rating scales were frequently used to evaluate EPS, but systematic methods were rarely applied to other treatment-emergent problems. The definition of individual adverse effects and the manner of reporting were inconsistent. Conclusions: The way in which safety and tolerability data are collected and reported in clinical studies does not allow for fair and meaningful comparison of the relative risk profiles of individual antipsychotic drugs.en
dc.description.urihttps://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/assessment-of-adverse-effects-in-clinical-studies-of-antipsychotic-medication-survey-of-methods-used/1BE34EE0AD37AD94954AA621C686B27F
dc.subjectDrug therapyen
dc.subjectData collectionen
dc.subjectPsychotic disordersen
dc.titleAssessment of adverse effects in clinical studies of antipsychotic medication: survey of methods useden
dc.typeArticle


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