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dc.contributor.authorPalaniyappan, Lena
dc.date.accessioned2017-09-20T15:57:54Z
dc.date.available2017-09-20T15:57:54Z
dc.date.issued2013
dc.identifier.citationPalaniyappan, L., Simmonite, M., White, T. P., Liddle, E. B. & Liddle, P. F. (2013). Neural primacy of the salience processing system in schizophrenia. Neuron, 79 (4), pp.814-828.
dc.identifier.other10.1016/j.neuron.2013.06.027
dc.identifier.urihttp://hdl.handle.net/20.500.12904/9903
dc.description.abstractFor effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed "frontal inefficiency," the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia.
dc.description.urihttp://www.sciencedirect.com/science/article/pii/S0896627313005436
dc.subjectBrain
dc.subjectNeural pathways
dc.subjectSchizophrenia
dc.titleNeural primacy of the salience processing system in schizophrenia
dc.typeArticle


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