Neural primacy of the salience processing system in schizophrenia
dc.contributor.author | Palaniyappan, Lena | |
dc.date.accessioned | 2017-09-20T15:57:54Z | |
dc.date.available | 2017-09-20T15:57:54Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Palaniyappan, L., Simmonite, M., White, T. P., Liddle, E. B. & Liddle, P. F. (2013). Neural primacy of the salience processing system in schizophrenia. Neuron, 79 (4), pp.814-828. | |
dc.identifier.other | 10.1016/j.neuron.2013.06.027 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12904/9903 | |
dc.description.abstract | For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed "frontal inefficiency," the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia. | |
dc.description.uri | http://www.sciencedirect.com/science/article/pii/S0896627313005436 | |
dc.subject | Brain | |
dc.subject | Neural pathways | |
dc.subject | Schizophrenia | |
dc.title | Neural primacy of the salience processing system in schizophrenia | |
dc.type | Article | |
html.description.abstract | For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed "frontal inefficiency," the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia. |