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dc.contributor.authorLiddle, Elizabeth B.
dc.contributor.authorLiddle, Peter F.
dc.date.accessioned2019-07-22T15:16:39Z
dc.date.available2019-07-22T15:16:39Z
dc.date.issued2019
dc.identifier.citationHunt, B. A. E., Liddle, E. B., Gascoyne, L. E., Magazzini, L., Routley, B. C., Singh, K. D., Morris, P. G., Brookes, M. J. & Liddle, P. F. (2019). Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin, 45 (4), pp.883-891.en
dc.identifier.other10.1093/schbul/sby117
dc.identifier.urihttp://hdl.handle.net/20.500.12904/9934
dc.description.abstractIntroduction: Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the 2 conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound [PMBR]), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR. Methods: One-hundred sixteen participants completed a visuomotor task while their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring cognitive-perceptual, interpersonal and disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for. Results: We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between interpersonal and disorganization factor scores. Conclusion: These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations.en
dc.description.urihttps://academic.oup.com/schizophreniabulletin/article/45/4/883/5095481en
dc.subjectSchizotypal personality disorderen
dc.subjectElectroencephalographyen
dc.subjectBrainen
dc.subjectMovementen
dc.subjectSelf reporten
dc.subjectSurveys and questionnairesen
dc.subjectInterpersonal relationsen
dc.subjectSchizophreniaen
dc.subjectCognitionen
dc.subjectMotor activityen
dc.subjectPerceptionen
dc.titleAttenuated post-movement beta rebound associated with schizotypal features in healthy peopleen
dc.typeArticleen


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